Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes during cellular differentiation
نویسندگان
چکیده
Addresses: Department of Biochemistry and Goodman Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec, Canada, H3G1Y6. Epigenetic Regulation and Chromatin Architecture Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Centre for Molecular Medicine, Robert-Rössle Strasse, Berlin-Buch 13125, Germany. Genome Function Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK. Dipartimento di Fisica, Università di Napoli Federico II, and INFN Napoli, CNR-SPIN, Complesso Universitario di Monte Sant’Angelo, 80126 Naples, Italy. MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK. RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Saitama, 351-0198 Japan. RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Kanagawa, 230-0045 Japan Stem Cell Neurogenesis Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
منابع مشابه
Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation
Mammalian chromosomes fold into arrays of megabase-sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher-order organization remains elusive. Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation an...
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تاریخ انتشار 2015